Tuesday, April 05, 2005

Function of Proteases and Side Effects of Protease Inhibitors

PROTEASE is responsible for digesting proteins in your food, which is probably one of the most difficult substances to metabolize. Because of this, protease is considered to be one of the most important enzymes that we have. If the digestive process is incomplete, undigested protein can wind up in your circulatory system, as well as in other parts of your body.

When you take protease in higher quantities, it can help to clean up your body by removing the unwanted protein from your circulatory system. This will help to clean up your blood stream, and restore your energy and balance. One of the tricks of an invading organism is to wrap itself in a large protein shell that the body would view as being "normal". Large amounts of protease can help to remove this protein shell, and allow the body's defense mechanisms can go into action. With the protective barrier down, your immune system can step in and destroy the invading organism.

PROTEASE INHIBITORS are pills that need to be taken at least twice a day supposedly to inhibit HIV from replicating. These protease inhibitors also inhibit the body's natural proteases that are required to digest proteins, which automatically throws your body out of homeostasis. This is why there is certain death for anyone taking the HIV/AIDS cocktails. Here are some pictures of the body deformations that these drugs cause.

PROTEASE INHIBITOR (SIDE) EFFECTS

Invirase &AEling; (Hoffmann-LaRoche)

Body as a whole: allergic reaction, chest pain, edema, fever, intoxication, parasites external, retrosternal pain, shivering, wasting syndrome, weight decrease.

Cardiovascular: Cyanosis, heart murmur, heart valve disorder,

hypertension, hypotension, syncope, vein distended.

Endocrine/Metabolic: Dehydration, dry eye syndrome, hyperglycemia, weight increase, xerophthalmia.

Gastrointestinal: Cheilitis, constipation, dysphagia, eructation, feces bloodstained, feces discolorred, gastralgia, gastritis, gastrointestinal inflammation, gingivitis, glossitis, hemorrhage rectum, hemorrhoids, hepatomegaly, melena, pain pelvic, painful defecation, pancreatitis, parotic disorder, salivary glands disorder, stomatitis, tooth disorder, vomiting.

Hematlogic: Anemia, microhemorrhages, pancytopenia, splenomegaly, thrombocytopenia.

Musculoskeletal: Arthralgia, arthritis, back pain, cramps muscle, musculoskeletal disorders, stiffness, tissue changes, trauma.

Neurological: Ataxia, bowel movements frequent, confusion, convulsions, dysarthria, dysesthesia, heart rate disorder, hyperesthesia, hyperreflexia, hyporeflexia, mouth dry, numbness face, pain facial, paresis, poliomyelitis, progressive multifocal leukoencephalopathy, spasms, tremor.

Psychological: Agitation, amnesia, anxiety, depression, dream excessive, euphoria, hallucination, insomnia, intellectual ability reduced, irritability, lethargy, libido disorder, overdose effect, psychotic disorder, somnolence, speech disorder.

Reproductive System: Prostate enlarged, vaginal discharge.

Resistance Mechanism: Abscess, angina tonsillaris, candidiasis, hepatitis, herpes simplex, herpes zoster, infection bacterial, infection mycotic, infection staphylococcal, influenza, lymphadenopathy, tumor.

Respiratory: Bronchitis, cough, dyspnea, epistaxis, hemoptysis, laryngitis, pharyngitis, pneumonia, respiratory disorder, rhinitis, sinusitis, upper respiratory tract infection.

Skin and Appendages: Acne, dermatitis, dermatitis seborrheic, eczema, erythema, folliculitis, furunculosis, hair changes, hot flushes, photosensitivity reaction, pigment changes skin, rash maculopapular, skin disorder, skin nodule, skin ulceration, sweating increased, urticaria, verruca, xeroderma.

Special Senses: Blepharitis, earache, ear pressure, eye irritation, hearing decreased, otitis, taste alteration, tinnitus, visual disturbance.

Urinary system: Micturition disorder, urinary tract infection.


Crixivan &AEling; (Merck, Sharp & Dohme)

Body As A Whole/Site Unspecified: Abdominal distention, chest pain, chills, fever, flank pain, flu-like illness, fungal infeciton, malaise, pain, syncope.

Cardiovascular System: Cardiovascular disorder, palpitation.

Digestive System: Acid regurgitation, anorexia, aphthous stomatitis, cheilitis, cholecystitis, cholestasis, constipation, dry mouth, dyspepsia, eructation, flatulence, gastritis, gingivitis, glossodynia, gingival hemorrhage, increased appetitie, infectious gastroenteritis, jaundice, liver cirrhosis.

Hemic and Lymphatic System: Anemia, lymphadenopathy, spleen disorder.

Metabolic/Nutritional/Immune: Food allergy.

Musculoskeletal System: Arthralgia, back pain, leg pain, myalgia, muscle cramps, muscle weakness, musculoskeletal pain, shoulder pain, stiffness.
Nervous system and Psychiatric: Agitation, anxiety, anxiety disorder, bruxism, decreased mental acuity, depression, dizziness, dream abnormality, dysesthesia, excitement, fasciculation, hypesthesia, nervousness, neuralgia, neurotic disorder, paresthesia, peripheral neuropathy, sleep disorder, somnolence, tremor, vertigo.

Respiratory System: Cough, dyspnea, halitosis, pharyngeal hyperemia, pharyngitis, pneumonia, rales/rhonchi, respiratory failure, sinus disorder, sinusitis, upper respiratory infection.

Skin and Skin Appendage: Body odor, contact dermatitis, dermatitis, dry skin, flushing, folliculitis, herpes simplex, herpes zoster, night sweats, pruritus, seborrhea, skin disorder, skin infection, sweating, urticaria.

Special Senses: Accommodation disorder, blurred vision, eye pain, eye swelling, orbital edema, taste disorder.

Urogenital System: Dysuria, hematuria, hydronephrosis, nocturia, premenstrual syndrome, proteinuria, renal colic, urinary frequency, urinary tract infection, urine abnormality, urine sediment abnormality, urolithiasis.
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